Israeli airline El Al will offer nonstop flights from Tel Aviv to Manchester three times a week from May 2019.
The route is scheduled to launch on May 26, 2019 and will operate on Mondays, Tuesdays and Thursdays.
The flights – numbered LY302 and LY301 – will be served by Boeing B737-800 aircraft configured with business and economy seating.
An introductory fares is running for bookings made by November 26, with flights from £199 one way and £289 return in economy (both hand baggage only) and £929 return in business.
The UK is currently connected to Tel Aviv via nonstop flights from London with Easyjet, Wizz Air and British Airways. Easyjet also offers twice-weekly Tel Aviv-Manchester flights.
El Al has previously offered nonstop flights between Tel Aviv and Manchester, but these were suspended in 2006.
El Al received its first Dreamliner last year and in October began offering a Premium class service on the B787 between Tel Aviv and Heathrow.
The airline was founded in 1948 and flies to 36 destinations, with the most direct flights to and from Israel.
Manchester Airport, the largest airport outside London, is undergoing a £1bn upgrade which will expand Terminal 2 by 150 per cent.
Julian Carr, Aviation Director at Manchester Airport, said: “We are delighted to welcome El Al to Manchester Airport with flights to Tel Aviv.
“The carrier will offer the 22 million passengers in our vast catchment area more choice and accessibility to this part of the world.
“I am sure it will prove hugely popular and look forward to flights commencing next year.”